Diversity
in Alzheimer's Disease
Research
Inclusion of diversity in the prevention and diagnosis of neurodegenerative diseases — the example of Alzheimer's disease.
An interactive, reproducible, open-science platform linking datasets, atlases, harmonisation pipelines, and an original reproducibility audit.
Project Structure
Three interconnected parts, each with dedicated sub-repositories.
The Need for Diversity
Defining Alzheimer's disease, its heterogeneity, and why diverse populations are essential for advancing research.
- ▸Defining AD & core mechanisms
- ▸A highly heterogeneous disease
- ▸Diversity that impacts AD
Initiatives Integrating Diversity
An interactive overview of global datasets, open-science efforts, harmonisation pipelines, and reproducibility initiatives.
- ▸Interactive world dataset map
- ▸Neuroimaging & genetics catalogue
- ▸Proteomics & exposomics
- ▸Open science & harmonisation
Reproducible Science
Three independent reproducible research sub-repositories contributing original analyses.
- ▸Dataset open documentation
- ▸Atlases & harmonisation catalogue
- ▸Reproducibility audit of A&D journal
Why diversity matters in AD research
The 2024 Lancet Commission identified 14 modifiable risk factors accounting for ~45% of dementia cases worldwide — yet the majority of evidence comes from high-income, predominantly European-descent cohorts. Genetic, environmental, and sex-specific risk factors remain poorly characterised in underrepresented populations.
Livingston et al., The Lancet 2024 · doi:10.1016/S0140-6736(24)01296-0